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DAPOXETINE
DABIGATRAN
DAPRODUSTAT
DIACEREIN
DONEPEZIL HYDROCHLORIDE
DOLUTEGRAVIR
DOSULEPIN
ELTROMBOPAG
ETODOLAC
IMEGLIMIN HYDROCHLORIDE
LULICONAZOLE
OXALAMINE
OXICONAZOLE NITRATE
MACITENTAN
MIGLUSTAT
NEBIVOLOL HYDROCHLORIDE
VODADUSTAT
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SITAGLIPTIN
TENELIGLPTIN
TICAGRELOR
TENOFOVIR ALAFENAMIDE
TOFACITINIB CITRATE
UMIFENOVIR
PROSTAGLANDINS (Under Development)
BIMATOPROST
CLOPROSTENOL SODIUM
DINOPROST
EPOPROSTENOL SODIUM
LATANOPROST
LUBIPROSTONE
MISOPROSTOL
TAFLUPROST
TRAVOPROST
ONCOLOGY
BENDAMUSTINE
BORTEZOMIB
CARMUSTINE
IMATINIB MESYLATE
SORAFENIB
PROSTAGLANDINS CATEGORY
MISOPROSTOL
S No Chemical Name CAS No Remarks
1 (3R)-5-Oxo-3-[(triethylsilyl)oxy]-1-
cyclopentene-1
-heptanoic Acid Methyl Ester
118456-54-5 Misoprostol/ main chain/ Purity-NLT-95 %
2 (E)-triMethyl((1-iodo-
4-Methyloct-1-en-4- yl)oxy)silane
62555-05-9 Misoprostol/ side chain/ Purity-NLT -90%
3 Methyl 7-((1R,2R,3R)-3-hydroxy-2-((S,E)-
4-hydroxy-4-methyloct-1-enyl)-5- oxocyclopentyl)heptanoate
59122-46-2 Misoprostol Oil/ Purity-NLT -90%
4 Misoprostol (1% HPMC dispersion) 103601-27-0 1 % Misoprostol
BIMATOPROST
S No Chemical Name CAS No Remarks
5 (3aR,4S,5R,6aS)-(-)-Hexahydro-5-
hydroxy-4-(hydroxymethyl)-2Hcyclopenta[
b]furan-2-one
32233-40-2 (-) Corey lactone diol
6 (3aS,4R,5S,6aR)-(+)-Hexahydro-5-
hydroxy-4-(hydroxymethyl)-2Hcyclopenta[
b]furan-2-one
76704-05-7 (+) Corey lactone diol
7 (3aR,4S,5R,6aS)-5-hydroxy-4-
(hydroxymethyl)-3,3a,4,5,6,6ahexahydrocyclopenta[
b]furan-2-one
54423-47-1 (±)-Corey lactone diol
8 Dimethyl (2-oxo-4- phenylbutyl)phosphonate 41162-19-0 Bimatoprost/lower wittig
9 5-(Triphenylphosphonio)pentanoic acid bromide, 17814-85-6 Bimatoprost/upper wittig
10 (3aR,4R,5R,6aS)-hexahydro-5-
triethylsilane-4-((E)-3-oxo-5-phyenylpent-
1- enyl)cyclopenta[b]furan-2-one
1190865-70-3 Bimatoprost intermediate after lower wittig
11 (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-
[(1E)-3-oxo-5-phenyl-1-penten-1-
yl]cyclopentyl]-N-ethyl-5-heptenamide
1163135-96-3 Bimatoprost 15-keto impurity
12 (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-
[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-
yl]cyclopentyl]-5-heptenoic Acid
38344-08-0 Bimatoprost acid
13 (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-
((E)-3-oxo-5-phenylpent-1-en-1-
yl)cyclopentyl)hept-5-enamide
155205-89-3 Bimatoprost des ethyl impurity
14 methyl (Z)-7-((1R,2R,3R,5S)-3,5-
dihydroxy-2-((S,E)-3-hydroxy-5-
phenylpent-1-en-1-yl)cyclopentyl)hept-5-
enoate
38315-47-8 Bimatoprost methyl ester impurity (n-1)
15 (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-
((R,E)-3-hydroxy-5-phenylpent-1-en-1-
yl)cyclopentyl)-N-ethylhept-5-enamide
1163135-92-9 Bimatoprost 15 epi impurity
16 (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-
((S,E)-3-hydroxy-5-phenylpent-1-en-1-
yl)cyclopentyl)-N-ethylhept-5-enamide
155206-00-1 Bimatoprost API
LATANOPROST
S No Chemical Name CAS No Remarks
17 (3aR,4R,5R,6aS)-hexahydro-5-hydroxy-
4-[(3R)-3-hydroxy-5-phenylpentyl]-2Hcyclopenta[
b]furan-2-one
145667-75-0 Latanoprost Lactone Diol
18 (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-
[(3R)-3-hydroxy-5-
phenylpentyl]cyclopentyl]hept-5-enoic
acid
41639-83-2 Latanoprost Acid
19 Isopropyl 4-(3-(((1R,2R,3R,5S)-3,5-
dihydroxy-2-((R)-3-hydroxy-5-
phenylpentyl)cyclopentyl)methyl)oxiran-2-
yl)butanoate
N/A Latanoprost Epoxy impurity
20 (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-
(3-oxo-5-phenylpentyl)cyclopentyl]-5-
heptenoic acid 1-methylethyl ester
135646-98-9 Latanoprost 15 keto impurity
21 Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-
dihydroxy-2-((S)-3-hydroxy-5-
phenylpentyl)cyclopentyl)hept-5-enoate
145773-22-4 Latanoprost 15 Epi impurity
22 Isopropyl (Z)-7-((1R,2R,3R,5S)-5-
acetoxy-3-hydroxy-2-((R)-3-hydroxy-5-
phenylpentyl)cyclopentyl)hept-5-enoate
913258-34-1 Latanoprost Trans impurity
23 Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-
dihydroxy-2-((R)-3-hydroxy-5-
phenylpentyl)cyclopentyl)hept-5-enoate
130209-82-4 Latanoprost API
TRAVOPROST
S No Chemical Name CAS No Remarks
24 Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-
dihydroxy-2-((S,E)-3-hydroxy-4-(3-
(trifluoromethyl)phenoxy)but-1-en-1-
yl)cyclopentyl)hept-5-enoate
1420791-14-5 Travoprost 15 epi
25 Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-
dihydroxy-2-((E)-3-oxo-4-(3-
(trifluoromethyl)phenoxy)but-1-en-1-
yl)cyclopentyl)hept-5-enoate
404830-45-1 Travoprost 15 keto
26 Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-
dihydroxy-2-((2S)-3-((S)-1-hydroxy-2-(3-
(trifluoromethyl)phenoxy)ethyl)oxiran-2-
yl)cyclopentyl)hept-5-enoate
N/A Travoprost Epoxy impurity
27 (Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-
{(R,E)-3-hydroxy-4-[3-
(trifluoromethyl)phenoxy]but-1-
enyl}cyclopentyl)hept-5-enoic acid
54276-17-4 Travoprost Acid impurity
28 Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-
dihydroxy-2-((R,E)-3-hydroxy-4-(3-
(trifluoromethyl)phenoxy)but-1-en-1-
yl)cyclopentyl)hept-5-enoate
157283-68-6 Travoprost API
29 dimethyl (2-(3-
(trifluoromethyl)phenoxy)acetyl)phospho nate
54094-19-8 Travoprost Side chain
CLOPROSTENOL
S No Chemical Name CAS No Remarks
30 15-epi Cloprostenol/(5Z)-7-
[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-
Chlorophenoxy)-3-hydroxy-1-buten-1-yl]-
3,5-dihydroxycyclopentyl]-5-heptenoic acid
54276-22-1 (+)-15(S)-CLOPROSTENOL
31 [1R-
[1alpha(E),2beta(1E,3R*),3alpha,5alpha]
]-7-[2-[4-(3-Chlorophenoxy)-3-hydroxy-1-
butenyl]-3,5-dihydroxycyclopentyl]-5-
Heptenoic acid
57968-81-7 (+)-trans Cloprostenol
32 (5Z)-7-{(1R,2R,3S,5S)-2-[(1E)-4-(3-
chlorophenoxy)-3-hydroxybut-1-en-1-yl]-
3,5-dihydroxycyclopentyl}hept-5-enoic
acid
40665-93-8 15S-(+/-)-Cloprostenol
33 (5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-
chlorophenoxy)-3-hydroxy-1-buten-1-yl]-
3,5-dihydroxycyclopentyl]-5-heptenoic
acid sodium
55028-72-3 Cloprostenol Sodium API
34 dimethyl (2-(3-
chlorophenoxy)acetyl)phosphonate
40665-94-9 Cloprostenol Side chain
CRABOPROST
S No Chemical Name CAS No Remarks
35 DIMETHYL (2- OXOHEPTYL)PHOSPHONATE 36969-89-8 Carboprost side chain
36 (Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-
((S,E)-3-hydroxy-3-methyloct-1-en-1-
yl)cyclopentyl)hept-5-enoic Acid
35700-23-3 Carboprost Acid
37 Methyl (E)-7-[(1S,3S,5R)-3,5-dihydroxy-
2-[(Z,3S)-3-hydroxy-3-methyloct-1-
enyl]cyclopentyl]hept-5-enoate
35700-21-1 Carboprost Methyl Ester
38 (5Z)-7- [ (1R,2R,3R,5S)-3,5-Dihydroxy-2-
[ (1E,3R)-3-hydroxy-3-methyloct-1-
enyl]cyclopentyl]hept-5-enoic Acid
35864-81-4 Carboprost 15 epi
39 (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxy-
15- methylprosta-5,13-dien-1-oic acid
with 2-amino-2-(hydroxymethyl)-1,3-
propanediol
58551-69-2 Carboprost Tromethamine
TAFLUPROST
S No Chemical Name CAS No Remarks
40 Dimethyl(2-oxo-3- phenoxypropyl)phosphonate 40665-68-7 Tafluprost \ side chain
41 (3aR,4R,5R,6aS)-4-[(1E)-3,3-Difluoro-4-
phenoxy-1-butenyl]hexahydro-5-hydroxy-
2H-cyclopenta[b]furan-2-one
209861-01-8 Tafluprost \ HF
42 (3aR,4R,5R,6aS)-;(3AR,4R,5R,6aS)-4-
((E)-3,3-Difluoro-4-phenoxybut-1-en-1-
yl)-2-oxohexahydro-2Hcyclopenta[ b]furan
209861-00-7 Tafluprost \ BF
43 7-[2-(3,3-difluoro-4-phenoxybut-1-enyl)-
3,5-dihydroxycyclopentyl]hept-5-enoic acid
209860-88-8 Tafluprost \ Acid
44 7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4- phenoxy-1-buten-1-yl]-3,5-
dihydroxycyclopentyl]-,1-methylethyl ester
209860-87-7 Tafluprost \ API
DINOPROST
S No Chemical Name CAS No Remarks
45 Dimethyl(2-oxo-3-
phenoxypropyl)phosphonate
551-11-1 Dinoprost acid
46 (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-
[(E)-(3R)-3-hydroxyoct-1-
enyl]cyclopentyl]hept-5-enoic Acid
37658-84-7 dinoprost 15 epimer
47 (5Z,9S,11S,13E,15S)-9,11,15-
Trihydroxyprosta-5,13-dien-1-oic acid
methyl ester
33854-16-9 Dinoprost methyl ester
48 (5Z,9α,11α,13E,15S)-9,11,15-
Trihydroxyprosta-5,13-dienoic acid tris
salt
38562-01-5 Dinoprost tromethamine (API)
49 (3AR,4R,5R,6aS)-5-Hydroxy-4-((S,E)-3-
hydroxyoct-1-en-1-yl)hexahydro-2Hcyclopenta[
b]furan-2-one
26054-67-1 Dinoprost intermediate
DINOPROSTONE
S No Chemical Name CAS No Remarks
50 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-
oxocyclopentyl)-5-
heptenoicaci;dinoproston
363-24-6 Dinoprostone API
51 (Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-
[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-
enoic acid
914804-63-0 Dinoprostone Keto impurity
52 (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E)-(3R)-
3-hydroxyoct-1-enyl]-5-
oxocyclopentyl]hept-5-enoic acid
38873-82-4 Dinoprostone epimer impurity
53 Z)-7-[(1S,2R,3R)-3-hydroxy-2-[(E,3S)-3-
hydroxyoct-1-enyl]-5-
oxocyclopentyl]hept-5-enoic acid
27415-25-4 Dinoprostone Acid
TREPROSTINIL
S No Chemical Name CAS No Remarks
54 1H-Benz[f]inden-2-ol, 2,3,3a,4,9,9ahexahydro-
1-[(1E,3S)-3-hydroxy-1-octen-
1-yl]-5-methoxy-, (1R,2R,3aS,9aS)
1903779-33-8 Treprostinil / advanced intermediates
55 1H-Benz[f]indene-2,5-diol,
2,3,3a,4,9,9ahexahydro-1-[(1E,3S)-3-
hydroxy 1-octen1-yl]-, 5-
1425937-55-8 Treprostinil / advanced intermediates
56 1H-Benz[f]indene-2,5-diol,
2,3,3a,4,9,9ahexahydro-1-[(1E,3S)-3-
hydroxy 1-octen1-yl]-,
1257983-83-7 Treprostinil / advanced intermediates
57 Acetonitrile, 2-
[[(1R,2R,3aS,9aS)2,3,3a,4,9,9a-hexahydro-2-
hydroxy-1- [(1E,3S)-3-hydroxy-1-octen-1-yl]-
1Hbenz[f]inden-5-yl]oxy]
1425937-57-0 Treprostinil / advanced intermediates
58 Acetic acid, [[2,3,3a,4,9,9a-hexahydro-
2hydroxy-1-(3-hydroxy-1-octenyl)-
1Hbenz[f]inden-5-yl]oxy]-, [1R-
[1α(1E,3S*),2β,3aα,9aα]]
81845-88-7 Treprostinil / advanced intermediates